The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid.

Simultaneous determination of four monoamine metabolites and serotonin in cerebrospinal fluid by "high-performance" liquid chromatography with electrochemical detection; application for patients with Alzheimer's disease.

We describe an optimized, sensitive assay procedure for simultaneously determining 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydroxyphenylacetic acid, and serotonin in human lumbar cerebrospinal fluid. The assay is based on liquid chromatography with an electrochemical detection system equipped with a newly developed, highly sensitive graphite electrode. Before assay, samples are deproteinized wit...

Significance and origin of DOPA, DOPAC, and dopamine-sulphate in plasma, tissues and cerebrospinal fluid.

Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with L-dopa.

The acid metabolites of dopamine and 5-hydroxytryptamine were estimated in the lumbar cerebrospinal fluid (CSF) of Parkinsonian patients both before and during treatment with l-dopa, the amino acid precursor of dopamine. An attempt was made to relate clinical improvement to the biochemical results. The dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, showed increases ...

Intraparenchymal delivery of GDNF towards a treatment for Parkinson’s disease

Abbreviations: 6-hydroxydopamine, (6-OHDA); adeno-associated virus, (AAV); Alzheimer’s disease, (AD); amyotrophic lateral sclerosis, (ALS); brain derived neurotrophic factor, (BDNF); Core Program for Intracerebral Transplantations, (CAPIT); central nervous system, (CNS); ciliary neurotrophic factor, (CNTF); cerebrospinal fluid, (CSF); dopamine, dopaminergic, (DA); deoxyribonucleic acid, (DNA); ...

Chlorpromazine attenuated electroacupuncture analgesia in conscious rabbits.

By measuring the defense behavior in response to the noxious stimulation induced by potassium iontophoresis on ear-lobe skin of conscious rabbit, chlorpromazine (CPZ) (0.5 mg.kg-1, i.v.) induced hyperalgesia, whereas it significantly attenuated electroacupuncture analgesia (EAA) efficacy. Monoamines and their metabolites in cerebrospinal fluid (CSF) were measured by high pressure liquid chromat...